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Drug Profile for Revolution (Selamectin)


Revolution® (brand name Stronghold® in Europe) is medication that treats and prevents a variety of parasites.

Active Ingredient: selamectin


Label indications vary by country. In the US, Revolution® is labelled for:


  • heartworm prevention
  • flea treatment and prevention
  • ear mite treatment
  • sarcoptic mange treatment
  • tick control


In Canada, Revolution® is also labeled as an aid in the treatment of roundworms. In Europe, Stronghold® is also labeled for the treatment of roundworms (T. canis) in dogs, and the treatment of biting lice in dogs and cats.

Dosage Forms
Revolution® (Stronghold®) comes in single dose tubes containing the appropriate amount of liquid for the treatment of either a dog or cat in a weight range indicated by the packaging.

Administration of Revolution®
Revolution® is a liquid that is applied to the skin on the back of the neck in front the shoulder blades - your vet will provide full instructions and precautions. It should not be rubbed in; it will quickly absorb into the body through the skin. It is applied monthly.

Other pets and children should be kept away from treated pets for about 30 minutes, until treated area is dry. After just a couple of hours, bathing or swimming will not affect the effectiveness of treatment.

Revolution should not be given orally or into the ear canal.

See product information in package for full information on precautions and safety.

  • For use in dogs 6 weeks of age and older and cats 8 weeks of age and older.
  • Revolution®/Stronghold® shouldn't be used on sick, debilitated or underweight animals.
  • Animals should be tested for active heartworm infections prior to using Revolution.
  • In humans, Revolution® sometimes causes irritation of the skin (hives, itchiness, redness). Always wash hands after applying it to your pet, and read the package insert for further safety information.

Side Effects

  • In cats, temporary hair loss, sometimes with irritation, has been noted at the site of application in approximately 1 percent of cats.
  • According the the product monograph, other possible (though infrequent) side effects seen during drug testing included: vomiting, diarrhea (sometimes with blood), loss of appetite, lethargy, rapid breathing, and muscle tremors. Other reported reactions include hives, itching, incoordination, fever, seizures, and death. As with any medication, the risks and benefits should be discussed with your vet, and any side effects reported to your vet immediately.

Please note: this article has been provided for informational purposes only. If your pet is showing any signs of illness, please consult a veterinarian as quickly as possible.

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