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Janet Tobiassen Crosby, DVM

ProMeris - Adverse Reactions Reported - Part I

By , About.com GuideApril 23, 2008

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A veterinary technician and former colleague forwarded an email to me and others, warning about serious adverse reactions after using ProMeris brand flea and tick control. Typical for an urban legend, the incident happened to someone else and she was unsure if the email was true, but felt that the warning was worthwhile. According to David Emery, the About.com Guide to Urban Legends, the circulating ProMeris email is currently classified as "unresolved."

Whether this particular incident happened or not, it is important to mention here that any drug or treatment, taken orally or topically, prescription or over-the-counter, has the potential to cause an adverse reaction. The same is true even if the medication was administered previously without problem. For this reason, if I need to medicate my pets, I always like to give the medication while I will be present; at least for an hour or two, if possible.

If you suspect that your pet is having or has had an adverse reaction, please call your veterinarian immediately. If you have questions about safety or reactions, please contact the Environmental Protection Agency (EPA) about pesticides such as ProMeris and other flea and tick treatments -- for pets or environmental use.

Story Update: Follow up to: ProMeris - Adverse Reactions: Viewers Respond

Related reading and in the news:

May 24, 2008 update: Viewer stories (email and from comments) along with a link to the official Fort Dodge response, have been published here.

Comments

April 30, 2008 at 10:10 am
(1) James TerBush says:

The email that is circulating around the Internet concerning an adverse reaction that allegedly occurred after using ProMeris may be true, or it may have been written by a sales rep for a competing product. Regardless, it’s important to know that ALL flea and tick control products are poisons (neurotoxins) and can cause severe adverse reactions in animals.

It’s best to thoroughly investigate ANY product before giving or applying it to your pet.

May 2, 2008 at 3:28 pm
(2) Jean Brudd says:

No product is 100 percent “safe.”

One should take the time to explore holistic options for flea and tick prevention. There are wonderful all-natural products on the market that do not contain harmful chemicals.

If your animal companion has a flea and/or tick problem, perhaps all that is needed is a change to an all-natural homemade diet, one that supports the immune system so that parasites and bugs are naturally repelled by the animal’s body. A good holistic vet can consult with you and come up with a tailor-made nutrition plan that is perfectly suited for your pet and your budget.

In spite of what manufacturers would like you to believe, they (and not even your vet) are not the experts regarding your pet’s health. No one knows your pet better than you do. It is up to you, as the pet’s guardian, to research, research, research, and then finally listen to your gut instinct BEFORE you ever agree to anything for your pet.

To further put things in perspective, if you would not use products in or on your human baby or yourself, stay away from them completely. When in doubt, do without!

May 12, 2008 at 9:37 pm
(3) Mayu says:

All flea and tick meds cause reactions, but I’ve been hearing more complaints about Promeris. I have also had issues with it. Not reactions – but the fact it doesn’t work. My vet who had switched completely to Promeris, switched completely back to Frontline after only a month. They have a FILE of complaints.

Perhaps all meds have issues… but this is a bit scary just how many issues promeris is having. I never had issues with Frontline, so if it ain’t broke, don’t fix it as they say.

May 24, 2008 at 9:35 am
(4) jameson says:

My bulldog just threw up for the third time after getting her first dose of Promeris. I wish that were an urban legend.

May 24, 2008 at 3:55 pm
(5) Vanessa says:

Jameson, I know how you feel. My cat’s eyes streamed like crazy and she threw up three times after I used Promeris. I was advised by the ASPCA to bathe her with a solution of Dawn dishwashing detergent, which worked…but I think I’d prefer dealing with fleas any day over attempting to bathe a cat! I too wish this were an urban legend.

May 28, 2008 at 10:17 pm
(6) george says:

Applied Promeris to my 6 year old Chow mix.
Terrible skin rash developed & fur fell out in clumps.
Hopefully this is all that will occur.
Had to take her to the vet, now on antibiotics.
Will be contacting the company that sells this crap.

June 17, 2008 at 2:22 am
(7) Denny says:

The first treatment went fine, except we still had ticks. The second treatment was 38 days later. I came home about two hours later and found her in the middle of the yard with her mouth on the ground with gravel in it, couldn’t hardly get her to wake up enough to get up and walk. She was shakey and twitching all over. This was on Friday afternoon. I took her to the vet on Monday afternoon and they shaved the spot on her back and down her side where the treatment burned her skin and was losing her hair. (about one and a half times of a softball)
She is still unsteady and lethargic and still has twitching problems of the head and front legs. When she is sleeping you have to shake her very hard and yell at her to wake her up.
I have used Frontline for years without problems, my vet switched to ProMeris this year, wish I had never given her the second dose. PLEASE DO NOT USE THIS ON YOUR DOG !!!

June 17, 2008 at 1:03 pm
(8) Marsha says:

My dog’s heart rate dropped to 48 after one dose of ProMeris. I got her to the vet and she was given an injection of Antisedan, which perked her up. I also gave her a bath as advised. But she relapsed within 3 hrs with a heart rate of 40. She ended up in ER for IV fluids and another dose of Antisedan, in addition to another bath. I applied the product as directed; I am a former vet asst with 16 yrs experience. Will go back to Frontline. My vet and the ER vet both told me they are seeing many similar reactions, and from what I understand, my case is not isolated.

June 28, 2008 at 9:58 am
(9) Randy says:

The vet gave my jack russel mix a dose of this stuff. She is completely zoned out and breathing slow with a slow heart beat. We took her back to the vet and they said it should be gone in a few hours, its normal. That was Friday, and today is Saturday. I called them and they said they’d get back to me. I don’t like this stuff. They gave it to her for her fleas AND her momma-mange. I wanna go back to the old mange medicine. She’s actually alive when she takes it…..

July 5, 2008 at 10:57 pm
(10) K Walker says:

Promeris has been a miracle for me and my dog. My five mo old red heeler had been suffering from demodectic mange. She was covered in bump and inflamed and itchy skin. She was constantly scratching and biting everywhere on her body. It was awful. Then our vet gave us Promeris. I gave her the dosage and didnt really have any problems with the smell. I later researched the product on the net and could have kicked myself for not doing it before i put it on my puppy. However now i am grateful that i didnt because i probably would not have ever given her the Promeris. In exactly one week she is basically “good as new”. The only adverse reaction that i noticed was that she had diarrhea the next day but that could also have come from her vaccines. Promeris worked great for us!!!

July 17, 2008 at 9:49 am
(11) Robert says:

I’m on my third dose of Promeris with my dogs. They have had few side effects other than a slight lethargy which lasted only a day.

New drugs like Promeris will have to be used instead of Frontline shortly, because fleas and ticks are building up an imunity to Frontline.

I have heard that it is important to wash your hands after giving Promeris… I have heard of cases where dogs licked each other or their owners and have gotten sick. That’s why it’s put on the dog’s back so they can’t lick it.

One other not is that the internet is a much bigger entity and more in people’s lives today than when Frontline first came out. Frontline probably had similar problems (and less people making things up. It’s important to be sceptical about anything you see on the internet not matter where and who claims to have posted it.

July 21, 2008 at 2:36 pm
(12) Dawn says:

My friend just lost her Best Puppy in Show over the weekend due to using ProMeris. It was stated in the initial report from the necropsy that the dog suffered anaphylactic shock from a chemical substance, and is currently being sent to the University to verify.

The dog showed signs of lethargy and would not eat, was not drooling, and was dead within 12 hours.

August 7, 2008 at 5:04 pm
(13) Cynthia says:

A little mutt (probably part Shiba Inu) took up with my dad 6-7 years ago. This dog was feral, so Dad hired a professional trainer to help him socialize the dog and teach her basic obedience. The trainer fell head over heels in love with the dog, and when Dad died, the trainer took the dog.

Yesterday the trainer called, devastated, to let me know that the dog had died. At her vet’s recommendation, she had switched from Frontline to ProMeris. She applied ProMeris for the first time on Tuesday afternoon. Wednesday morning, while she and the dog were taking their first walk of the day, the dog suddenly collapsed, seizing violently. She convulsed hugely for about a minute — seizures so strong that her body actually came off the pavement. Then she died.

The trainer has worked with dogs, breeding and training, for more than 30 years. She absolutely knows how to apply flea medication properly. She presently has no other dogs in her home, so the dog didn’t lick ProMeris off another dog. There is little chance that the dog ingested the drug. The proper dose was used, it was applied properly, and less than 24 hours later an otherwise healthy dog was dead.

It’s possible ProMeris was not at fault, that this is just coincidence, but given that this dog had no history of seizures yet died from a seizure soon after receiving a drug known to cause seizures, it’s suspicious. The dog’s body has been sent to a medical school for necropsy.

August 10, 2008 at 9:16 am
(14) mandyg says:

my dog collapsed and almost died 6 hours post application of this product. he displayed a lot of the symptoms previously mentioned and his heart rate was 40. thankfully i was around to start emergency treatment, (I am a qualifed veterinary nurse), whilst waiting for the vet to arrive.
on contacting the company i discovered that not only are they not surprised by the severity of the reaction but there are european clinical trials being done in september to find out why! I was so angry as we are still selling this product in practices.
my boss is having a meeting with one of the reps in a few weeks and i would appreciate it if people would find the time to email me their experiences.
many thanks
mandygvn79@yahoo.com

August 10, 2008 at 11:42 am
(15) Cindy says:

My mom put ProMeris on her 13 year old Jack Russell last month and he developed a red skin rash, but she wasn’t sure if he had gotten into something like poisen ivy or if it was the ProMeris. The ProMeris hasn’t worked as good as the Frontline had but her vet recommended that she try it again. She put the ProMeris on him for his second application a month later, yesterday, and after an hour she left, when she got home six hours later he had a seizure and then was very lethargic. She managed to get the vet to meet her at the clinic and the vet shampooed and rinsed him three times. His temperature was low, she gave him an IV with medication added to it. His temperature was still low and his glucose level was slightly elevated, but they thought that could be because my mom had fed him while trying to get in touch with the vet. The vet recommended not letting him get too warm or too cold and too watch him closely. This morning he seems much better. He is still not 100% and is panting but is not as lethargic and seems more normal. She will take him back at some point to have his blood levels checked again to make sure that he does not have liver or kidney damage.

This stuff is dangerous!

August 18, 2008 at 2:40 pm
(16) Lynn M says:

My dog–a 10 yr old wheaten terrier–is having a reaction to ProMeris today after applying it for the first time, yesterday afternoon. She was very groggy this morning, eyes glazed, looked as if she’d been under anesthesia. She had occasional shuddering, back leg twitching and weakness in back legs. No vomiting. She seems to be less groggy now at noontime. When I called the vet’s office they said it was likely she’d ingested some and that it should wear off in a day or so. While it’s possible that she was petted last night and then licked a hand, we won’t be using this product again.

August 26, 2008 at 9:52 am
(17) Blue says:

The rumors about Promeris are not rumors. We had unfortunatly let our Vet “test out” promeris on our 15 week old dog. I wish we learned more about it ahead of time.
It was a near fatal reaction to the medicine. 72 hours of hoping that the dog would keep breathing. It also created unstoppable hair loss, which we are still trying to solve.
I say…listen to the rumors…DO NOT RISK YOUR PETS LIFE. Promeris is not GOOD!

September 5, 2008 at 11:02 am
(18) Robert Large says:

Our 60 lb. Chow mix had been administered Frontline for years, with effacacy and no adverse reaction. Our Vet changed the script to Promeris with no verbal side effect warnings. Upon administration of the first dose (there was NO internal ingestion), our dog within 3 hours experienced stumbling. lethargy, disorientation, drooling, rapid heart rate and respiration, huge thirst, and finally a seizure. Neither our Vet, nor the ER Vet were aware of these side effects because of “the newness of the product”. After viewing all the reports on so many websites, this hardly seems to be Urban Legend. I feel Promeris is unsafe and should be pulled from shelves and NEVER be prescribed by any knowledgeable Vet!

September 18, 2008 at 11:46 pm
(19) Kristy says:

I tried ProMeris on my 2 1/2 pound teacup shorkie, because my vet said that this new treatment is especially good for tiny dogs. He has been very groggy all day, but he did eat and drink a lot. I am pretty worried about him because he is so small. I will be calling my vet tomorrow. We have a German Shepard who uses the generic drops, and they have been fine, the only reason I asked the vet about my tiny dog is because all the generic stuff is for larger dogs (meaning more than 2 lbs.) I hope I didn’t do the wrong thing by trying this medication!

September 30, 2008 at 2:55 am
(20) Linda says:

My four month old puppy (jack russel cross) developed mange. Really horrible stuff. Took him to the vet started him on a dipping routine. 3ml dip to 1 litre water – every five days. That didn’t work. Second time round to the vet, more injections, more hair loss and more itching. The vet gave me ProMeris to try for mange. I have 2 cats and 2 dogs none of which have fleas or ticks. So why the vet prescribed ProMeris – I don’t know. I fortunatley didn’t have any side affects as many of you did, but his condition did not improve. His hair is falling out a lot more than it was in the beginning and bites himself like made. We are on round THREE to vet tomorrow.

My heart is sore for all of you who lost their little furry children.

October 5, 2008 at 2:56 pm
(21) Lee says:

For all of you out there who have used or are thinking of using Promeris, I recommend that you don’t. I have ten dogs so, needless to say, once we started having a flea problem it escalated out of control very quickly. We tried Frontline, Hartz bansect and sergeants products. All with no luck. I heard of Promeris from our vet and decided to give it a try. I applied the product according to the package directions. The smell was horrible. I had to take all of them outside for several hours before the smell was tolerable enough to bring them back in. After approximately 12 hours, 9 of my ten dogs became ill. They were very lethargic, had no appetite and we practically had to force them to drink water. My daughter and I became light headed and we both suffered terrible headaches just from the smell. Everyone was back to normal a day later but we could still smell the product. Now, a week later….. we still have fleas. It is not a product I would recommend or ever use again.

October 24, 2008 at 8:14 am
(22) Christy says:

I applied Promeris to my Chihuahua. Within hours she became lethargic, fearful and aggressive. This lasted for 48hrs. As a vet-tecnician, I suggest you leave this product alone. My baby is feeling much better today (day 3) but I will never use the product again. (We removed all of this product from our shelves.)

December 2, 2008 at 7:08 pm
(23) Sylvia Anglen says:

A vet student who boarded her horse with me told me about Promeris. I have a dog with Demodectic Mange that was a year round problem. After one application, he stopped itching, his hair grew back. his energy is back, eyes bright, and he and I are both thrilled! I have had nothing but good results with this product, and will continue to use it. Vigorous hand washing after administering it is needed.

April 12, 2009 at 2:17 am
(24) Phil says:

I think before making up things about urban legends, unless you have sold your sold your soul to Fort Dodge, you would better off having a more cautious and scientific approach.
I own a 5.5 year old female Cavalier King Charles, and the nearly nearly passed away after an application of Promeris, that we had tried on recommendation from our vet (we used to use Frontline). A couple hours after the application, our dog started fainting, and could not stand on its leg anymore. My wife had the good reaction to wash the dog immediately and thoroughly, and we took the pet to the emergency local vet (it was in the evening) where th dog stayed overnight for observation, and did fine in the end.
It tells me one thing: there are adverse reactions to Promeris, and the level of due diligence and vetting done and blessed by EPA on vet products seems to be something that is neither thorough, nor very scientific.
If this was a drug for human, Wyeth and Fort Dodge would have had a class action lawsuit on their hands for a while.

April 12, 2009 at 8:59 pm
(25) Phil says:

Some internet researches are showing that the EPA takes the problem seriously:
http://www.epa.gov/pesticides/foia/reviews/281250/281250-2006-11-30a.pdf
they seem to question Fort Dodge marketing of that drug for puppies, which at least is a start, but I can see most adverse reactions accounts here and elsewhere on adults dogs and cats instead.

Their European counterparts reports similar issues too:
http://www.emea.europa.eu/pdfs/vet/press/pr/39100906.pdf
though the fact that the drugs was still approved for marketing is beyond me.

For the full list of EPA reports on Promeris:
http://www.epa.gov/pesticides/foia/reviews/106201/
http://www.epa.gov/pesticides/foia/reviews/281250/

To get a feel fort it, I am quoting excerpts from page two of the report below which is a report based on test submissions to the EPA by Fort Dodge (NB: this dates from 2006!)
http://www.epa.gov/pesticides/foia/reviews/106201/281250-2006-08-21c.pdf
“COMMENTS AND RECOMMENDATIONS:

Overall, the findings from these studies do not indicate that an adequate margin of safety exists between the companion animal (dog) use exposure and that at which symptoms of toxicity occur. This is particularly evident in the Chihuahua study (MRID 46672102), in which possible indications of toxicity occurred at 1X. [Editor note: meaning this is a potentially toxic product even at normal dose]

[...]

All animals survived until the termination of the study. There were no treatments-related effects in any of the dog on body weight, hematology and clinical chemistry parameters or overall general health. Clinical signs observed immediately after treatment included: hyperactivity (4/6 treated dogs) and pruritis (5/6 treated dogs) with pruritus occurring for up to 7 hours . Lacrimation occurred in 1/6 of treated dogs 24 hours after the first application and in a different treated dog immediately after the 2nd application. The only female dog in the treatment group vomited one time on the first day post-treatment with both treatments suggesting a treatment-related effect. A small swelling was also observed at the area of application in 3/6 treated dogs at day 2, 7 and 11 post-application but was gone by day 21. None of these clinical signs was observed in the untreated control dogs.

This 21-day toxicity study in the dog is UNACCEPTABLE/NONGUIDELINE and does not satisfy the guideline requirement for a companion animal safety study. Only one dose level was tested and the number of animals tested (5 males and 1 female) was inadequate.
[...]”

The rest of this and others EPA reports above is just raising red flags all over:
- Fort Dodge does not follow EPA guidelines
- Fort Dodge own testings submitted to the EPA show adverse reactions.

They are finding that all is well, though dogs are doing adverse reactions. Go figure.

IMHO that drug should not be on the market.

April 20, 2009 at 2:04 pm
(26) vetmedicine says:

Hello – I didn’t make anything up about urban legends. When this story first came out, it was from a circulating email, from a friend of a friend (real source unknown), which is true of many urban legends. I felt that the story, whether that particular incident was true or not, was worthwhile; as are talking about any potential adverse drug reactions.

From subsequent viewer input in this thread and the posted update on this site from June of 2008, it has been confirmed that Promeris reactions are real.

Please report any problems to your veterinarian or consider reporting them yourself to the FDA, who monitors adverse drug reactions.

August 5, 2009 at 10:14 am
(27) Charles Crolley says:

After applying Promeris to my 85lb black lab, she was very lethargic. Now, 3 weeks later, she has huge welts between her shoulders. She’s had other topical medicines applied before, all without a hitch.

I followed the instructions to the letter. She could not possibly have ingested it, unless she rolled on something and then licked it up. (And how does one control that?)

I thought at first it was a singular allergy in this dog, but the more I read about other reactions and people dismissing the reports as kooks, sales reps, and crackpots, the madder I get.

Thanks to Phil, (Post 25) for the helpful links.

August 23, 2009 at 2:11 pm
(28) Paula says:

I used promeris last night on my pekingesse, and she just has a severe seizure. It was applied between the shoulder blades, she was the only dog to have the treatment so she could not have licked it off another dog. I dont know if she had any over the night, has anyone else reported seizures. She has never has a seizure. she does have a allergy to fleas, thus why we were using promeris????

September 8, 2009 at 6:37 pm
(29) WC says:

Folks, not saying that every pet is going to have a bad reaction to this but I am here to tell you that our bouncey and energetic terrior got a dose of this and the next day it was like we had doped her up with thorzine. She is extrmely lethargic and panting and needing a lot of water…
Use this stuff with caution!

November 1, 2009 at 8:27 pm
(30) ryan says:

NEVER use this stuff.we uses it on Our 9 month old great pyrneese. Since we put it on he is afraid of us. We have tried to wash it off But he keeps running away. He is itchy and rashy. and his back is very hot and flakey.

January 12, 2010 at 11:20 pm
(31) Steve says:

Only have used Promeris twice for Demodectic Mange. The first time it seemed to do the trick, the second time I thought it killed the dog. There is quite obviously something in this product that isn’t right. Too many adverse reactions to be misuse.

February 3, 2010 at 12:37 am
(32) Paul R. Nelson says:

We were prescribes ProMeris for our 12 week old Lab/Pointer mix due to demodex that cropped up shortly after we brought him home from the shelter. The “puppy” doses worked fine to clear up the demodex, with no bad reactions. As the months went by, he grew in size, requiring the larger dog dosage. The first time I applied this to him (around 7 months) he was fine. When it came time for the next dose a month later, he acted like it was burning his skin and would hardly let me put it on him. Other than extremely flaky skin confined to the application site, he was OK, luckily. However, we will not be using this product anymore due to the apparently painful reaction our puppy suffered. The tragic accounts listed by others only reinforce our decision.

March 4, 2010 at 12:10 pm
(33) Annelise Engelbreg says:

I will never again use promeris. We used it on our great dane puppy twice for demodex mites. After using it the first time she had very bad diarrhea, but we (and the vet) never thought it could be promeris, so kept on treating the demodex (although promeris was not needed agin). We battled for months to try and stop the diarrhea, which eventually ended after lots of money spent,tests done, different food, special food etc etc. A year later she again have what we think may be demodex, so again we used promeris (according to the vet’s advise). Immediately, she was tired, seemed depressed and suddenly incontinent! We phoned the vet that same noght and the next day, but according to them, the incomtinence cannot be as a resualt of the promeris. One of the active ingredients in promeris is ‘amitraz’ which has quite a lot of side effects – including incontinence! So that was it, we washed it off the next day and hopefully she’ll be back to normal soon. DON’T USE IT

April 22, 2010 at 4:10 am
(34) Kathy says:

My American Bulldog was prescribed Promeris for demodex mites after a having a reaction to Ivermectin, (a powerful and dangerous insecticide), which was initially prescribed. From that drug she had difficulty walking, lethargy, drooling. So I gave Promeris a try. After two months of treatment, the mange cleared up. The only thing I noticed was her skin around the application site was very red, and she had flakes on her coat. I was not sure whether it was from her coat or her skin. Now after reading other comments I realize it was her skin peeling off. I didn’t give it to her for a couple months because I didn’t want it to burn her skin, but just gave another application because the mange is returning. The effects of mange outway what she experienced with the promeris and worked before. Mange can eventually lead to bacterial infections which can lead to death. But since this last dose given about five days ago, I have noticed an increase of salivation. I am also noticing a skin rash, and small red bumps are coming on the insides of her legs/thighs. A couple of them are getting bigger. I don’t know if this is related since AB’s are prone to skin issues. I applied this last does further up above her shoulder blades and she didn’t have the skin reaction this time. However, I think the salivation is an indication of some effect on her nervous system. After reading all of the comments I am now afraid to give it to her again. From many of the comments I have read, it appears that a lot of folks used the promeris after giving their dogs other products. I am wondering just how long any of these products stay in a dog’s system and some of these reactions could be due to a overload of these insecticide chemicals. I will explore more treatments for the mites, and I don’t think I will use Promeris again. As much money as we spend on our pets, the ecomomy benefits, so I think someone should lobby for pets rights and the ability to make class action lawsuits in regards to our pets.
To me my dog is a people too!

May 26, 2010 at 1:33 pm
(35) jennifer says:

This is a warning to everyone with pets, this is my own personal story I have or had a great dog he was a 9 1/2 year old big and beautiful German Shepard he has always been healthy , but like most dogs he is allergic to fleas I usually buy advantage when i dont have the advantage he was on Adams flea spray until i can get to the vets for more, went to get more advantage from a closer vets office not my regular vet and the vet tech said maybe it isn’t working anymore here try this PROMERIS K9 he got so sick ( throwing up , diarrhea, couldn’t walk, wouldn’t eat or drink lethargic. i also bought his first pigs ear from the dog store gave both to him on the same day Friday night is when he got really sick. Monday vet said that the pig ears have salmonella, thought thats what it was. I thought he was getting better he was on some medicine from the vet and died 10 days later . I went and read about the promeris after he died i never would have bought it….. now i dont have him anymore.

July 17, 2010 at 8:54 pm
(36) Kim says:

My 4 and a half year old Pomeranian had been given Promeris every month for almost a year. As well as our 7 yr old half lab/golden retriever. i am such a bad mom…both dogs were lethargic and you could also tell it bothered their skin. The smell was so toxically strong that we had to treat them in the morning and leave them outside all day to keep from getting sick ourselves. Twice we did it at night and I got severe headaches and nausea from the smell. You would think this would tip me off that we should use less of the product or stop altogether. Instead, my Pom had a golfball sized cancerous tumor removed in the spot that we administered the product. Tell me that isn’t strangely obvious! They said it was the worst type….Adenocystic Carcinoma. Luckily it was all contained and removed, but I have thrown away all of the Promeris and have gone all natural!

July 22, 2010 at 11:27 am
(37) MariaElena Piccirillo says:

Below is a letter/email I began mailing and posting to alert the public of the harm ProMeris caused to my beloved feline companion of 4 years. The emotional distress his sudden and preventable passing has caused to me – heartrending. As I am left with nothing but a costly veterinary bill.

WARNING dated 6/2/2010: In Memory Of My Precious Preston – ProMeris flea prevention/control dangerous to your pet/pets.

I wish I would have goggled and read through the numerous post, emails, blogs, and websites that warned about the danger to using ProMeris before applying it to my sweet boy. Not to mention the recent EPA reports I’ve since read. I can assure you that this is not an urban legend – as I just lived through it.

I applied ProMeris to my four year old domestic black and white male cat Preston on Friday, May 29, 2010. On June 1, 2010 I had to put him to sleep due to kidney failure. Although, his vet couldn’t say for that it was the ProMeris. She did say that some poison/toxin caused the failure. Preston was a healthy and happy cat until I applied this product. Now after a four day stay in the hospital he is no longer with me. His vet’s attempts to flush his system with fluid therapy and antibiotics in hopes of restoring normal kidney functioning couldn’t undo the damage. Why is this product still on the market! This product is extremely dangerous and should be removed until its safety can be guaranteed.

Heartbroken in Florida

September 22, 2010 at 9:47 pm
(38) Melissa says:

We gave our 6 month old pug puppy, Atticus, his second dose of Promeris yesterday morning. His first dose was given on 8/17/10. He was prescribed Promeris as a solution to demodex mange. After the first application, he was completely fine! His mange cleared up in less than two weeks, which we thought was just amazing. We had been using a topical gel for a few weeks prior to Promeris with no results. We were thrilled that the Promeris seemed to clear up his demodex so quickly. After his second application yesterday afternoon, we noticed he got a little strange.
He is normally a very active, happy puppy. He had no interest in his toys, or treats, or doing his tricks. He threw up, which was very alarming because we’ve had him since he was 12 weeks old and he had never thrown up before. His eyes have been glazed over and watery. His lethargy has lasted into today, but he ate breakfast this morning and went for a nice walk with me this evening. He threw up again tonight, and is still not very interested in playing and hasn’t eaten anything since this morning. My boyfriend and I have been worried about him, and after reading the posts in this thread I’m almost positive that he is reacting to the Promeris. We purchased six applications, but I think since the demodex is cleared up we will be switching to Frontline, or some other form of flea/tick prevention. I plan on calling the vet tomorrow if he is still acting funny, but as I type this he is playing with his toys in his bed, which is a good sign because he hasn’t touched them since Monday night. (He LOVES his toys, so this was odd to us.)

February 10, 2011 at 11:09 am
(39) Linda G. says:

I.m currently using promeris, 3rd app.(3rd scrip) its not helping, hes fine for 2 weeks (apply every 2 weeks)Also antibiotics. hes a year old, found abanded w/ sis and bro, they are fine. Help

February 17, 2011 at 11:40 am
(40) Bobby Sánchez says:

I bought ProMeris for my 11 dogs a week ago today. Our vet stopped carrying K-9 Advantix, and she recommended we try PM. Knock on wood, we’ve had NO negative reactions from the use of this product, and I am completely satisfied with the results – no fleas or ticks on any of our ‘kids’, and being on a small farm, our flea and tick problems can be quite severe.

March 18, 2011 at 10:37 am
(41) bob says:

our vet determined our 55 lb. dogs reaction to promeris was low blood sugar and recommended a tbls of karo syrup in his food immediately prior t and following o application. This has greatly reduced any reaction to nil.

March 31, 2011 at 1:16 pm
(42) Steph C. says:

Myself, my parents, and my friend all use Promeris. Between a total of 7 dogs we have had no adverse reactions. In fact it has become the opposite. Frontline, Advantage, etc were not working anymore. My dog had a reaction to Comfortis so we tried Promeris. It works great, yes it has a smell but not intolerable.

As a licensed vet technician I tend to notice that whenever a dog becomes ill people immediatly blame the flea product (regardless of the brand) if it was applied within a certain amount of time. I am not saying that is the case with every report on here, but do remember that not everyone is a veterinarian. Sometimes as humans we jump to conclusions or “dramatize” a story.

Like anything, yes there will be pets that are allergic and have a reaction. We take a risk putting any sort of chemical based product on our dogs, but the alternatives are home based remedies that don’t work (I have tried them) or allowing our pets to be miserable.

If you are trying a new product on your dog, apply a partial dose and watch closely. If you think that they are having an adverse reaction immediatly wash the area with Dawn dish soap and call your vet. A proper dose of Benadryl can also help (make sure to talk to your vet first!).

Remember tens of thousands of pet owners have switched to Promeris, so just because you have read postings on the internet about how “bad” a product is there are tons of stories that are not posted about how good it has worked.

If it was truly a deadly product veterinarians would not sell it. The vet I work for would never dream of selling a product that kills dogs! Many of our clients have switched with no issues and have reported a higher success rate than with Frontline/Advantage.

March 31, 2011 at 2:16 pm
(43) Beth says:

My 4 yr. old dog died 8 hours after applying Promeris. Urban legend? Yeah, right. I’ve rescued for over 12 years. I applied this product(correctly) to 7 of my rescues including my personal shep/collie mix. I found him with his eyes fixed and he was barely breathing. He died in my arms moments later. This product should(in my opinion) be used strict
ly by prescription only and soley for severve cases of mange.

May 8, 2011 at 10:11 am
(44) Amanda says:

I didnt go down thru and read all the comments, but I did read #10… My 14, almost 15yr old JR/Beagle mix also has demodectic mange! Out of 4 dogs, 3 cats, he is the only one that picked up the mange, FROM A COYOTE! Promeris has saved my kids life! I apply it every month now and he’s in great shape, back to his usual normal spunky self and for a dog this old, he acts as if he is 8, 9! Yes the smell is strong and he seems a lil out of it the next morning, but it clears up and the mange stays away! If I dont apply it, he gets the mange back within a month! We have treated our yard to kill the mange but how can you do that when you live in the hills of WV and there are coyotes going through the yard every night! I will continue to use promeris as long as i need to and as long as my bubba stays healthy! The promeris kills the mites but what most ppl dont realize, when these mites die, they release a toxin themselves! So is it really the promeris causing some of these reactions or the mites dying off!? My dog was soooo infected, it took 4 months to clear him up completely and its been one hella rough road but we are back and stronger then ever!

May 16, 2011 at 6:18 pm
(45) PATPOMS says:

Just to warn people, it might not affect one dog but could another, I treated several of my dogs, only one of them became deadly ill, he had stopped going to the bathroom, stopped eating, poor coordination…just really acted totally out of it. Emergency vet gave him a shot to reverse the affects, immediately he started going to the bathroom everywhere. I swore I would never use it again, regardless if it did fine for my other dogs. I called to report to the company the affects of promeris, they said he must have ingested it (don’t think so). Well a couple of years later, my dog is still not right, he still wobbles, does not act all there at times. And this problem did not start till I used Promeris. People think of the long term affect this product can have on your precious pets. None of my vets carry this product any longer because of all the bad reports.

July 9, 2011 at 10:30 am
(46) angie says:

I have been using ProMeris for months now and have not had any problems. I learned about ProMeris through other people. I was telling them about stuff not working on my dogs. They use ProMeris as well and love it.

July 20, 2011 at 12:03 pm
(47) JoJo says:

I applied Promeris to my 4 dogs for the 2nd time since purchasing it. They have not had an adverse reaction, however I came home from work 2 weeks ago and one of my cats, who has not been treated with cat Promeris, had had a grand mal seizure and can no longer eat or drink – does not know what food is anymore from the brain damage!! After $300 at the Vet and no “reason” for what happened to her and the subsequent brain damage, I am sure that it was contact with the dogs immediately following the Promeris treatment – I will not be using it again and endanger them or the other cats in my home!!!

September 25, 2011 at 2:39 am
(48) Jenn says:

I just have to say I have been using Promeris on my bulldog with severe demodectic mange since 2008, and it is the ONLY thing that has helped him. We spent 2 years trying every single treatment option out there to try to help him, and nothing worked completely. Every month we battled bacterial infections caused by his scratching the hairless areas caused by the demodectic mange. We tried every food option we could find, tested for allergies, nothing worked. He was on steroids, 3 different topical medications, continuous antibiotics, and Ivermectin all at once yet at least 50% of his body was hairless. We spent over $3000 in his first 2 years of life trying to free our dog of these awful skin problems. Then our vet introduced us to Promeris. Within 2 months our dog was off all the other medication, and his skin was looking better. His hair grew back in all but one area on his tail, his skin infections became non-existant, and he went from spending his life scratching and whimpering to enjoying it. We haven’t had any adverse reactions at all, and I thank Promeris for allowing him to live a healthy and happy life. We will continue using Promeris because it is the only solution that has worked for us.

September 30, 2011 at 11:48 pm
(49) Mike says:

My new rescue puppy (5 months old) developed mange and the vet recommended Promeris. They applied it at the vets office today and told me to leave her for several hours for “observation”. I picked her up 4 hours ago and they handed me a lethargic, listless pup. I assumed it was the trauma of being at the vet but then I found this site and now know it’s the Promeris. We just gave her a bath to try to wash it off and she actually seems a little better but I’m still not ruling out a trip the emergency vet in the middle of the night. I will never know whether this product actually works because the immediate side effects were so severe. I hope she’s ok tomorrow. Right now I’m worried sick.

December 24, 2011 at 1:02 am
(50) Karen says:

On Saturday Sept. 4 , 2010 I used promeris flea drops on my minature Schnauzer . I applied the drops around noon. She became ill about 24 hours later vomiting and up everything she ate. The next day when she could not even keep water down . I took her to the vet and she had amitraz tox. from the pormeris flea drops. Treatment was started for gastroenteritis- foreign body infectious. Antibiotics were given along with a pill to help with the vomiting. I continue the medicines for the week plus left her at daycare for the remainered of the week, After meds were completed went back for a recheck.Around the end of oct I noticed she (Jazzy ) started sneezing so after about a week I decided to take her back to the vet with the cold , sneezing and nasal discharge. She was given a shot of antiobics. and a antihistamie . which did not seem to take care of the cold. I then took her back to the vet was given another round of antibotics. Nothing seem to help. even with continued visits to the vet. Then on Sat Nov 27 th she had a seizure I then rushed her to the vet and I found out that her sugar was very low and the liver counts were elevated. She had a week long hospital stay without improving much . I then found a vet with a ct scan which I took Jazzy for a scan to make sure no tumors were present. None were seen . I was told that the stomach area looked strange. But no tumors or anything like that was present. My Jazzy died on Dec 6th 2010 she was 7 years. old and I believe that the toxins she got from promeris flea drops killed her. Not because she licked them because she did not. These flea drops are toxin and the toxins lead to her death. . My Jazzy went to the vet very few times before the promeris flea drops came into the picture.

February 16, 2012 at 6:41 pm
(51) Karen says:

I just ordered promeris for my cat. Now after reading this stuff I’m scared to put it on her. She suffers from continuous demodex mange and it is causing us in the household to itch too. This has been going on for years and we’ve hoped that Promeris would end this problem. We love our cat and dont’ want to kill her! She is like my child…

May 4, 2012 at 10:56 pm
(52) Lisa says:

Our story with promeris began when we took our 8 month old shihtzu to the vet and they told us he had demodex mites and they put an application of promeris on him in the office. within one hour he was like a zombie for twelve hours and then he started with severe itching and scratching. He started losing mobility in his back legs. Four trips to vet and emergency vet in four days. I believe it attacked his nervous system. We are on day five now and he lost hair on the neck where it was applied with bloody spots. He is losing hair on his back and acts extremely uncomfortable. He has been put on antibiotics, antihistimines, eye antiobiotics and muscle relaxers due to extreme twitching. My puppy was the happiest playful dog in the world and then came promeris. Only time will tell if he will ever recover.

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